For some reason I cannot get the Z2 to click and drag across programs, it always "lets go" once another window is in focus. I have the left button configured correctly in the Global profile (press and release) and no other profiles change this behaviour. This only seems to happen with different programs, i.e having two Explorer windows open works as expected, but going from Explorer to Firefox releases the button during the transition. Below is the issue in action, using the Z2 first and another mouse second:

As shown, once Alt-Tab is released, the Swiftpoint mouse releases the button and control over the file is lost. Doing the same with another mouse keeps the file held after switching programs.

The left button in my profile is below: